Leisure, Lifestyle & Wellness
Researchers zero in on 'culprit' causing heart failure
Researchers have identified what they describe as "the long-sought culprit" that contributes to heart failure.
 
The research, published in the journal Nature, revealed that an enzyme called PDE-9 interferes with the body's natural "braking" system needed to neutralise stress on the heart.
 
"Like a play with multiple characters, heart muscle function is the result of a complex but perfectly synchronised interaction of several proteins, enzymes and hormones," said lead investigator Dong Lee, cardiology research associate at the Johns Hopkins University School of Medicine in the US.
 
Naturally found in the gut, kidneys and brain, PDE-9 is already a prime suspect in neurodegenerative conditions such as Alzheimer's, the researchers said.
 
But the new study shows that the enzyme's footprints are also present in heart cells and markedly elevated in patients with heart failure - evidence that PDE-9 is a multi-tasking "offender" and a key instigator of heart muscle demise, they added.
 
Working with lab animals and human heart cells, the scientists found that the enzyme PDE-9 wreaks mischief by gobbling up a signalling molecule, cGMP, which normally stimulates the production of a heart-protective protein called PKG.
 
The protein PKG is known to shield the heart muscle from the ravages of disease-causing stress, such as long-standing high blood pressure.
 
To understand the enzyme's role, the scientists exploited the knowledge that heart muscle health is safeguarded by two separate mechanisms, or signalling pathways.
 
Nearly a decade ago, researchers identified the culprit responsible for breakdown in one of the signalling pathways, an enzyme called PDE-5. Ever since then scientists have searched for the second "offender" that causes glitches in the other pathway.
 
The discovery of PDE-9 provides that long-sought break in the case, the researchers said.
 
In the current study, PDE-9 blockers not only stopped heart muscle enlargement and scarring in mice with heart failure, but they nearly reversed the effects of the disease.

User

Global Mount Money asked to cease and desist from acting as Investment Adviser
These entities were engaged in providing investment advisory services to public at large without obtaining requisite registration from SEBI for the same and as a result have violated provisions of the SEBI Act, 1992 and SEBI (Investment Advisers) Regulations, 2013
 
A SEBI Order directed Global Mount Money Research and Advisory and its directors and related entities to cease and desist from acting as Investment Adviser and cease to solicit or undertake such activities or any other unregistered activity in the security market directly or indirectly.
 
These entities have further been directed to immediately withdraw and remove all advertisements, representations, literatures, brochures, materials, publications, documents, websites etc. in relation to his investment advisory or any unregistered activity in the securities market.
 
These entities were engaged in providing investment advisory services to public at large without obtaining requisite registration from SEBI for the same and as a result have violated provisions of the SEBI Act, 1992 and SEBI (Investment Advisers) Regulations, 2013.
 
SEBI received information in respect of the activities of a Madhya Pradesh-based entity viz. Global Mount Money Research and Advisory Pvt. Ltd. (Global Mount) providing investment advice to general public through its website (www.globalmountmoney.co), without obtaining necessary registration from SEBI. When SEBI wrote to them for information about their activities, no reply was forthcoming. A SEBI official then visited the office of Global Mount at 504, Shagun Tower, Plot no. 07, PU-04, Scheme no. 54, Vijay Nagar Square, A B Road, Indore, Madhya Pradesh on December 24 and December 31, 2013 to obtain information about the working of Global Mount. It was found that the entity was carrying out investment advisory services in shares, derivatives and commodities. The website of Global Mount claimed the following strengths:
 
(a) Global Mount Money Research and Advisory is one of the India’s finest research and stock advisory company deals in intra-day tips and positional tips. We provide equity tips as well as commodity tips.
 
(b) We offer diversified range of services as per the investments of an investor, trader or a broker. Global Mount Money offers best stock future tips.
 
(c) In stock cash tips we provide intraday and positional services. In which we provide tips on cash scripts with most accurate level.
 
Subsequent to this, SEBI undertook a preliminary examination of the activities of Global Mount. One of the SEBI officers, posed as an ordinary investor, registered for free trials on the website of the entity viz. www.globalmountmoney.co. On successful registration, a representative of Global Mount contacted at the mobile number given at the time of registration for free trials.
 
SEBI also contacted the entities’ bankers and obtained information about them.
 
From the information gathered by SEBI, it observed:
 
(a) Rajeev Singh Rajput, Arpit Kothari and Ajay Kumar are collecting funds from investors for providing investment advice in the name of different company/ firms /proprietary concern viz. M/s Global Mount Money Research and Advisory Pvt. Ltd., Global Mount Money Research and Advisory, Global Money Financial Services and Global Money Research and Advisory.
 
(b) It is further observed that Global Mount Money Research Advisory Pvt. Ltd. (Company), Global Mount Money Research and Advisory (Partnership firm) and Global Money Research and Advisory (proprietary firm) are operating as one entity as is evident from the website of Global Mount, wherein at the home page, the entity was mentioning itself as Global Mount Money Research and Advisory and as a company. It is relevant to note that all the bank accounts given on the webpage are of the proprietary firm, viz. Global Money Research and Advisory. It is observed that all the directors of Global Mount are partners of the firm, Global Money Financial Services.
 
(c) As has been observed earlier, one of the directors of Global Mount, viz. Rajeev Singh Rajput is the proprietor of Global Money Research and Advisory. Two of the directors of Global Mount,  Rajeev Singh Rajput and Arpit Kothari are partners of the firm Global Mount Money Research and Advisory. It is also noted that all the three directors of Global Mount, viz. Rajeev Singh Rajput, Ajay Kumar and Arpit Kothari are partners of Global Money Financial Services.
 
(d) It is further noted that website of Global Mount, i.e. http://www.globalmountmoney.co, the name of the entity is mentioned as Global Money Research and Advisory (proprietary firm).
 
(e) The entity is claiming to have 4,232 active clients.
 
(f) High Accuracy is claimed by the entity, in their tips without any substantial evidence for the same.
 
(g) Marketing executives of the firm calls prospective clients for registration as free trial clients. Also, some clients register for free trials after pursuing the website of Global Mount.
 
(h) Tips are being provided to the investors through SMS/calls as evident from the SMS tips and calls received by the SEBI Official, who had registered for free trial, as an ordinary investor.
 
(i) Bank Account details are mentioned on the website for online payment. From bank statements provided by the respective banks, it is evident that there is a regular flow of funds in bank accounts of the entity from various individuals across the country which is equivalent to fees charged by the entity for his advisory services.
 
This is the nature of business being carried out by the entities.
 
Hence, SEBI in its Order observes, “SEBI has been entrusted with the duty to protect the interests of investors and protect the integrity of the securities market. Considering the facts and circumstances of the present matter and on the basis of prima facie findings, it is necessary to intervene in this matter to take immediate steps to prevent such persons from engaging further clients. This is also a case where, effective and expeditious action is required to be taken to prevent any possible harm to investors caused by the unauthorized activities of the aforementioned entities and its Directors/ Partners/ Proprietor.
 
Hence, SEBI issued the “cease and desist” order mentioned earlier and also instructed the entities from advertising their services.
 
SEBI has also maintained that this Order does not stop it from taking any further action against the entities carrying out the unregistered activity of Investment Adviser.
 

 

User

'Cinderella' - a fairytale full of life's lessons
"Cinderella"; Cast: Cate Blanchett, Lily James, Richard Madden, Helena Bonham Carter, Nonso Anozie, Stellan Skarsgard, Sophie McShera, Holliday Grainger, Derek Jacobi, Ben Chaplin, Hayley Atwell, Rob Brydon and Eloise Webb; Director: Kenneth Branagh; Rating: ***
 
Disney's live-action film "Cinderella", crafted with pomp and splendour as a typically traditional fairytale by director Kenneth Branagh, reiterates the oft heard story of how an orphan girl, harassed by her cruel step-mother and equally harsh step-sisters, marries a Prince. Laced with life-lessons for everybody, this film is more than just a sweet fantasy romance drama.
 
The tone of the narration is laid at the very beginning, when little Ella (Eloise Webb) tells her mother, "I believe in everything". And, as the story unravels, you are aware of what to expect and yet, wonder how the film got its name Cinderella, when the protagonist is called Ella.
 
The telling has all the elements like a caring father, a nasty step-mother Lady Tremaine and her daughters Drisella and Anastasia, Prince Charming, Fairy Godmother, the Pumpkin turning into a carriage, the mice into horses, lizards as footmen, the goose as the carriage rider and the glass shoes. They make you nostalgic.
 
As the story moves at a brisk pace with a few distinctively funny and emotional moments, you are glued to the screen. You simply become aware of the freshness of the approach and the simple, yet minute, logical stances that the director takes. And where it deviates and expands upon, it does so in ways that add nuance and depth. These help not only to make the tale credible, but likeable also.
 
The film belongs to television actress Lily James who plays the grown-up Cinderella. Her sweet demeanour is reflected by her "kindness and courage". And physically, her transformation from a housemaid to "the beautiful princess to be" is mesmerising. Aptly paired opposite her is Richard Madden, the charming Prince who she fondly refers to as "Mr. Kits". The onscreen chemistry between them is palpable and that makes their romance believable.
 
Ben Chaplin and Hayley Atwell as Cinderella's loving and caring biological parents are functional. Their scenes with Cinderella are synthetically sweet. Their equation seems tailored to heighten the contrast delivered by the antagonists.
 
Cate Blanchett as Mrs. Tremaine, Sophie McShera as Drisella, Holliday Grainger as Anastasia and Helena Bonham Carter as the Fairy Godmother make their presence felt with dramatic overtures. Their scenes are theatrical and engaging.
 
The dialogues are characteristically a Disney product -- very crisp, chirpy and intermittently spiked with tasteful and elegant humour.
 
Visually, the elaborate earthy and picturesque sets by production designer Dante Ferrett, period costumes by Sandy Powell and fine performances by the actors are brilliantly captured by cinematographer Haris Zambarloukos. With smooth camera movements, his wide angle shots, especially the colourful ballroom scene and the last mastershot, are compelling.
 
The computer generated images are of fine quality and captivating. The dancing butterflies, the digitally rendered animals and their magical transformation along with Cinderella's makeover, mesh smoothly into the live-action drama. Cinderella's race against time when she has to return home before the last stroke of midnight is thrilling, as well as fascinating.
 
In modern times and with a questioning audience, the only issue this timeless classic faces is its oversight to justify how could Cinderella have a laidback attitude and wait for destiny to play its part? And the uncalled for, deliberate low-neck gowns that the ladies wore at the ball gave the scene a vulgar tinge.
 
Nevertheless, this "Cinderella" with "her courage, kindness and a little bit of magic" is worth a watch.

User

We are listening!

Solve the equation and enter in the Captcha field.
  Loading...
Close

To continue


Please
Sign Up or Sign In
with

Email
Close

To continue


Please
Sign Up or Sign In
with

Email

BUY NOW

The Scam
24 Year Of The Scam: The Perennial Bestseller, reads like a Thriller!
Moneylife Magazine
Fiercely independent and pro-consumer information on personal finance
Stockletters in 3 Flavours
Outstanding research that beats mutual funds year after year
MAS: Complete Online Financial Advisory
(Includes Moneylife Magazine and Lion Stockletter)